All Roads Lead to Brampton

From the Lester B. Pearson International Airport:

Follow the Highway signs to Highway 427 South
South on Hwy. 427 to Hwy. 401
West on Hwy. 401 to Hwy. 10 (Hurontario Street)
North on Hwy. 10 to downtown Brampton (Queen Street) 

From Downtown Toronto:

Take the Gardiner Expressway West
The Gardiner Expressway becomes the QEW (Queen Elizabeth Way)
West on QEW to Highway 427
North on Hwy. 427 to Highway 401
West on Hwy. 401 to Hwy. 10 (Hurontario Street)
North on Hwy. 10 to downtown Brampton (Queen Street)  

From Ottawa: 

South on Hwy. 416 (Turns into Hwy. 6) to Highway 401
West on Hwy. 401 to Hwy. 10 (Hurontario Street)
North on Hwy. 10 to downtown Brampton (Queen Street)  

From Montreal:

East on Hwy. 20 to Hwy. 401
West on Hwy. 401 to Hwy. 10 (Hurontario Street)
North on Hwy. 10 to downtown Brampton (Queen Street)  

From Buffalo:

Cross the Peace Bridge to the QEW (Queen Elizabeth Way) East
Take the QEW East to Hwy. 403 East
East on Hwy. 403 to Hwy. 410 North to Brampton
North on Hwy. 410 to Steeles Avenue
West on Steeles Avenue to Hwy. 10 (Hurontario Street)
North on Hwy. 10 to downtown Brampton (Queen Street)  

From Detroit/Windsor/London: 

Take Hwy. 401 East to Hwy. 10 (Hurontario Street)
North on Hwy. 10 to downtown Brampton (Queen Street)